Mechanisms of the Cytotoxic Action of Organotin Compounds
نویسندگان
چکیده
This review analyzed the literature data on in vitro preclinical study of cytotoxic properties organotin compounds, as well main mechanisms their action. The latter consist interacting with SH groups proteins, initiating oxidative stress, binding to DNA, receptors, activate apoptosis by increasing expression caspases, proapoptotic and decreasing antiapoptotic proteins. Organotin depending donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. high potential indicates possibility further development vivo research compounds candidates for creation drugs anticancer antimetastatic therapy.
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ژورنال
عنوان ژورنال: Biomedicina
سال: 2021
ISSN: ['2386-6942']
DOI: https://doi.org/10.33647/2074-5982-17-2-88-99